Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Coronavirus Disease 2019 (COVID-19) infections are the three epidemiological diseases caused by the Coronaviridae family . Perceiving the immune responses in these infections and the escape of viruses could help us design drugs and vaccines for confronting these infections . This review investigates the innate and adaptive immune responses reported in the infections of the three coronaviruses SARS, MERS, and COVID-19 . Moreover, the present study can trigger researchers to design and develop new vaccines and drugs based on immune system responses . In conclusion, due to the need for an effective and efficient immune stimulation against coronavirus, a combination of several strategies seems necessary for developing the vaccine.