For social work practitioners in healthcare settings, self-care can be an integral tool to assuaging stressors associated with COVID-19 . However, research that examines the impact of public health crises, such as COVID-19, is nominal, at best . This exploratory study investigated the impact of COVID-19 on the self-care practices of self-identified healthcare social workers (N = 2,460) in one southeastern state . Primary data were collected via an electronic survey and assessed via a retrospective pre/post design . Analyses compared practices before and after COVID-19 was declared a pandemic . Overall, data suggest that participants experienced significant pre/post decreases in self-care practices across multiple domains . As well, findings indicate that participants who identified as married, financially stable, and working non-remotely, and in good physical/mental health engaged in significantly more self-care practices than other participants, at post . This study underscores the need to foster supportive professional cultures that include developing self-care practice skills, particularly during large-scale crisis, such as COVID-19.