Background: Coronary artery disease (CAD) has been recognized as a major determinant of Covid-19 vulnerability and severity We sought to compare demographic characteristics, clinical presentation, and outcomes for Covid-19 in a large cohort of chronic CAD patients living in Strasbourg's cluster region (Fig 1)

Methods: Follow-up was conducted by telephone interviews performed by cardiologists one month after the start of the French lockdown The primary outcome was the composite of death or hospitalization related to Covid-19 infection Secondary endpoints included Covid-19 related death, Covid-19 related hospitalization, intensive care unit (ICU) admission, allcause mortality, cardiovascular (CV) mortality and healthcare compliance

Results: Out of 891 patients included, twenty CAD patients (2 2 %) had RT-PCR confirmed Covid-19 infection Confirmed or suspect cases were evidenced in 48 patients (5 4 %) Covid-19 patients showed lower left ventricular ejection fraction, were more frequently obese, less likely to smoke or follow lipid lowering therapy The composite of death or hospitalization related to Covid-19 was 90% Mortality rate was 30% among confirmed Covid-19 patients Drugs ’ discontinuation rate was low (1 1 %) during the confinement Reticence to consult a healthcare professional occurred in 6 4% Postponement or cancellation of non-essential medical visits occurred in 15,7% (Table 1)

Conclusions: Coronary patients from a large French cluster of COVID-19 showed a high risk of Covid-19 infection and worse in-hospital outcomes