In December 2019, WHO was informed with several unknown pneumonia cases and later it was found as highly contagious, transmittable and pathogenic viral infection . The novel coronavirus (nCoV-19) was firstly reported from Wuhan city in China . COVID-19 has raised the concern of the world since its emergence from China . The WHO has declared an ongoing COVID-19 outbreak as a pandemic . Till now 6,057,853 confirmed cases with 371,166 deaths have been reported from approximately 213 countries of the world . The aim of this study is to discuss all the aspects related to recently discovered novel coronavirus . The article, therefore, provides a comprehensive study on the genomic, epidemiological, social, clinical and environmental aspects of SARS-CoV-2 . SARS-CoV-2 uses human ACE2 receptor as a ligand to bind and transmit its genome just like the SARS-CoV . The clinical symptoms of SARS-CoV-2 are very non-specific and include fever, sore throat, wheezing, rales, headache and rhinorrhoea with round-glass pulmonary opacifications shadowing in X-ray . Many antiviral drugs show efficacy but only in mild to moderate infection levels . Though efforts on development of SARS-CoV-2 vaccine have been started earlier as soon as the pandemic was emerged, till date no effective drug or vaccine has been validated with significant efficacy against the disease; therefore, there is a dire need to design effective vaccine against SARS-CoV-2 . Multiple vaccine candidates are still in evaluation and exploratory stages on different clinical models with potential results on different animals and human models . mRNA-1273, ChAdOx1, Ad5-nCoV, INO-4800, LV-SMENP-DC and pathogen-specific aAPC are the most advanced and potential drug candidates against COVID-19 . Recent studies have revealed any attractive vaccine candidates as promising therapeutic agents based on different strategies of vaccines . Here, the rationale of this review was also to provide an overview of the pathogenesis of the virus and summarize the updated potential vaccine candidates against SARS-CoV-2.