In order to treat severe acute respiratory syndrome coronavirus (SARS-CoV), till now no such specific treatment is available . Various coronaviruses (CoV) such as SARS-CoV, MERS-CoV (Middle East Respiratory Syndrome), SARS-CoV-2 can infect human and the name was implicated due to their crown shape . SARS-CoV-2 is also called COVID-19 which was found to be a novel strain of coronavirus and is transmitted primarily through small droplets of viral particles that targets human body through the open pathways . Researchers have observed that microbes can survive for a longer duration they get adhered to any object or surface . Nanoparticles have giant capability to disable these pathogens even before they enter the body . To eradicate conventional time consuming steps like quantitative real time polymerase chain reaction for detection of COVID-19, nanoparticles mediated sensing approaches is providing a great advances in rapid diagnosis . Nano particles based biosensors are comparatively beneficial which offer tremendous potential for rapid medical diagnosis . Nanotechnology can be refined and optimized to attack a wide variety of pathogens . As compared to other large molecular structures, nanoparticles being small in size have huge sensitivity for bio-sensing and can move throughout the body without providing any disruption in the immune functioning.