COVID-19 has a wide spectrum of clinical phenotypes . While fever and cough are the most common symptoms, abdominal pain is rarely reported . We report the first case of COVID-19 pneumonia in an elderly patient with multiple myeloma (MM), complicated by acute calculous cholecystitis (ACC). A 73-year-old gentleman with underlying IgG kappa MM, presented with fever, cough and dyspnoea . His nasopharyngeal swab was positive for SARS-CoV-2 . Piperacillin/tazobactam and oral hydroxychloroquine were started in addition to granulocyte colony-stimulating factor (GCSF) support due to neutropenia . Patient deteriorated on day 5, requiring high flow oxygen support . Dexamethasone, low molecular weight heparin prophylaxis and one dose of intravenous immunoglobulin were given . Despite negative swab on day 10, he developed ACC on day 17 . With antibiotics and supportive care, patient showed full recovery without any surgical intervention . It remains elusive whether the gallbladder might be vulnerable to COVID-19, necessitating further validation via prospective studies.