Self-sampling is poised to be a disruptor for cervical screening . So far, cancer screening has been a causality of COVID-19; however, the opposite may transpire for self-sampling . Self-sampling enables socially distanced cervical screening with an outreach that extends to underserved populations . As evidence mounts that self-sampling is noninferior to clinician-taken samples, the focus for self-sampling is now as a primary screening option for all women . Now, we have evidence from a modeling study (using Australia as an exemplar) to suggest that program effectiveness with primary self-sampling would be better than the current program, even if sensitivity is lower . Regulatory issues, suitable triage strategies, and clear communication about self-sampling are hurdles yet to be overcome . Nevertheless, existing evidence coupled with COVID-19 could be the tipping point for wider introduction of self-sampling.See related article by Smith et al., p. 268.