In December 2019, COVID-19 broke out in Wuhan, China, affecting the mental health and quality of life (QoL) of its inhabitants . This study aimed at investigating the factors associated with anxiety and QoL in the Wuhan populace during the COVID-19 pandemic . An online questionnaire survey was carried out during July 6-10 , 2020 . The questionnaire collected information on demography, anxiety, QoL, and social-environmental support . The main statistical methods included descriptive statistics, independent-samples t-test, one-way analysis of variance, and multivariate regression analysis . In total, 226 participants were recruited . The findings showed that females, elderly, middle-income, poor health status, shortage of medical supplies, and insufficient basic commodities were associated with anxiety significantly . Multiple regression analysis indicated that social-environmental support was significantly related to anxiety . Higher social-environmental support was significantly associated with a higher QoL . Our findings showed that the social-environmental support may reduce anxiety and improve the quality of life for those living in an area heavily affected by the pandemic . This article is protected by copyright . All rights reserved.