Lipids play an essential role in platelet functions . It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events . The ongoing increase in cardiovascular diseases ’ incidence emphasizes the importance of research linking lipids and platelet function . In particular, the rebound phenomenon that accompanies discontinuation of clopidogrel in patients receiving dual antiplatelet therapy has been associated with changes in the lipid profile . Our many years of research underline the importance of reduced HDL values for the risk of such a rebound effect and the occurrence of thromboembolic events . Lipids are otherwise a heterogeneous group of molecules, and their signaling molecules are not deposited but formed “ on-demand ” in the cell . On the other hand, exosomes transmit lipid signals between cells, and the profile of such changes can be monitored by lipidomics . Changes in the lipid profile are organ-specific and may indicate new drug action targets.