The COVID-19 pandemic itself and related public health measurements have had substantial impacts on individual social lives and psychological and mental health, all to the detriment of health-related quality of life (HRQoL). There have been extensive studies investigating the mental health of people in different populations during the COVID-19 pandemic . However, few studies have explored the impact of COVID-19 and its association with HRQoL . To fill this research gap and provide further empirical evidence, this study examined the impact of COVID-19 on Hong Kong people and evaluated its association with HRQoL . A total of 500 participants were randomly recruited to complete an online questionnaire on their concerns related to COVID-19 . This entailed responding to the World Health Organization Quality of Life-BREF instrument . Data were collected between 24 April and 3 May 2020 . Independent t-tests and multiple linear regressions were used to examine the association between the impact of COVID-19 and HRQoL . Overall , 69.6% of participants were worried about contracting COVID-19, and 41.4% frequently suspected themselves of being infected . Furthermore , 29.0% were concerned by the lack of disinfectants . All of these findings were associated with poorer HRQoL in the physical and psychological health, social relationships, and environment domains . On the other hand , 47.4% of participants were concerned that they may lose their job because of the pandemic, while 39.4% were bothered by the insufficient supply of surgical masks . These two factors were associated with poorer HRQoL in the physical and psychological health and environment domains . The adverse impact of COVID-19 on individuals is multifactorial, affecting all aspects of HRQoL . In addition to enhancing anti-epidemic efforts, it is equally important to implement public health and social welfare measures, thereby diminishing the adverse impact of COVID-19 on overall well-being.