The COVID-19 pandemic has been accompanied by rapidly emerging evidence, changing guidance, and misinformation, which present new challenges for health literacy (HL) and digital health literacy (DHL) skills . This study explored whether COVID-19-related information access, attitudes, and behaviors were associated with health literacy and digital health literacy among college students in the United States . Self-reported measures of health literacy, along with items on pandemic-related attitudes, behaviors, information sources, and social networks, were collected online using a managed research panel . In July 2020 , 256 responses were collected, which mirrored the racial/ethnic and gender diversity of U.S. colleges . Only 49% reported adequate HL, and 57% found DHL tasks easy overall . DHL did not vary by HL level . In multivariable models, both HL and DHL were independently associated with overall compliance with basic preventive practices . Higher DHL, but not HL, was significantly associated with greater willingness to get a COVID-19 vaccine and the belief that acquiring the disease would negatively impact their life . On average, respondents discussed health with 4–5 people, which did not vary by HL or DHL measures . The usage of online information sources varied by HL and DHL . The study findings can inform future student-focused interventions, including identifying the distinct roles of HL and DHL in pandemic information access, attitudes, and behaviors.