INTRODUCTION: The immune system could be affected by a mixture of factors . It is customary to classify factors that affect the immune system into three main groups: hereditary, environmental and hormonal factors . When those factors deviate from their normal physiological effect, in the genetically pre-dispositioned, an autoimmune disease may erupt and a lymphoma may develop as a result . Viruses are a significant part of the environmental factors that affect the immune system . Recent evidence demonstrates the ability of the COVID-19 virus to induce hyper-stimulation of the immune system, thus leading to the formation of autoantibodies in patients . This effect of the COVID-19 virus is caused by two main courses of action: firstly, its ability to induce hyper-stimulation of the immune system; secondly, its molecular similarity to humans . Numerous records demonstrate the tendency of severely ill COVID-19 patients to develop multiple autoantibodies known to be found in common autoimmune diseases, such as antinuclear antibodies, antiphospholipid antibodies, and many more . Additionally, many case reports have been published on COVID-19 infected patients who developed autoimmune diseases . It is extremely important to recognize the autoimmune effects of the COVID-19 virus when dealing with the ongoing pandemic.
MeSH: Autoantibodies, Autoimmune Diseases, epidemiology, COVID-19, Humans, Pandemics, SARS-CoV-2