The immunomodulatory effect of vitamin D and its potential in prevention and treatment of acute respiratory infections have long been of interest to many scientific teams around the world . Several meta-analyses in the last 10 years have confirmed the protective (albeit of modest size) effect of vitamin D against respiratory infections . Because of many overlapping risk factors for vitamin D deficiency and severe COVID-19 infection, many experts believe that vitamin D supplementation could play an important role in prevention and treatment of the new coronavirus disease . Based on available data on the immunological action of vitamin D, it is possible that vitamin D could modulate the bodys response to SARS-CoV-2 infection both in the early viraemic phase and in later hyperinflammatory phase typical for the severe course of the disease . The first available data from epidemiological studies suggest that low serum vitamin D levels are associated with increased susceptibility to the new coronavirus infection as well as with severe course of the disease.
MeSH: COVID-19, Coronavirus Infections, Dietary Supplements, Humans, SARS-CoV-2, Vitamin D, Vitamin D Deficiency, drug therapy, prevention & control
Index: 25(OH)D, COVID-19, SARS -CoV-2, Vitamin D, acute respiratory infection, cardiovascular diseases, cathelicidin, prevention, treatment, vitamin