This review is about the development and use of vaccines from the early smallpox vaccine in the 18th century to the forthcoming SARS-CoV 2 vaccines . Immunisations have been of paramount importance for childhood mortality and public health in general, but some obstacles have also been encountered such as vaccine failures and vaccine scepticism . This calls for continued emphasis on large phase three studies not only for demonstration of efficacy but also for safety and possible side effects . The rapid approval of SARS-CoV 2 vaccines requires special attention.
MeSH: COVID-19, prevention & control, COVID-19 Vaccines, Child, History, 18th Century, History, 19th Century, History, 20th Century, History, 21st Century, Humans, SARS-CoV-2, Smallpox Vaccine, administration & dosage, history, Vaccines, history