BACKGROUND: In today's world, coronavirus disease 2019 (COVID-19) is the most critical health problem and research is continued on studying the associated factors . But it is not clear whether endometriosis increases the risk of COVID-19 .

METHODS: Women who referred to the gynecology clinic were evaluated and 507 women with endometriosis (case group) were compared with 520 women without endometriosis (control group). COVID-19 infection, symptoms, exposure, hospitalization, isolation, H1N1 infection and vaccination, and past medical history of the participants were recorded and compared between the groups using IBM SPSS Statistics for Windows version 21 .

RESULTS: Comparison between the groups represent COVID-19 infection in 3.2% of the case group and 3% of the control group (P = 0.942). The control group had a higher frequency of asymptomatic infection (95.7% vs. 94.5% ; P <0.001) and fever (1.6% vs. 0% ; P = 0.004), while the frequency of rare symptoms was more common in the case group (P <0.001). The average disease period was 14 days in both groups (P = 0.694). COVID-19 infection was correlated with close contact (r = 0.331; P <0.001 in the case group and r = 0.244; P <0.001 in the control group), but not with the history of thyroid disorders, H1N1 vaccination, traveling to high-risk areas, and social isolation (P> 0.05).

CONCLUSION: Endometriosis does not increase the susceptibility to COVID-19 infections, but alters the manifestation of the disease . The prevalence of the disease may depend on the interaction between the virus and the individual's immune system but further studies are required in this regard.