At the time of the prevalence of coronavirus disease 2019 (COVID-19), pulmonary fibrosis (PF) related to COVID-19 has become the main sequela . However, the mechanism of PF related to COVID (COVID-PF) is unknown . This study aimed to explore the key targets in the development of COVID-PF and the mechanism of d-limonene in the COVID-PF treatment . The differentially expressed genes of COVID-PF were downloaded from the GeneCards database, and their pathways were analyzed . d-Limonene was molecularly docked with related proteins to screen its pharmacological targets, and a rat lung fibrosis model was established to verify d-limonene's effect on COVID-PF-related targets . The results showed that the imbalance between collagen breakdown and metabolism, inflammatory response, and angiogenesis are the core processes of COVID-PF; and PI3K/AKT signaling pathways are the key targets of the treatment of COVID-PF . The ability of d-limonene to protect against PF induced by bleomycin in rats was reported . The mechanism is related to the binding of PI3K and NF-κB p65, and the inhibition of PI3K/Akt/IKK-α/NF-κB p65 signaling pathway expression and phosphorylation . These results confirmed the relationship between the PI3K-Akt signaling pathway and COVID-PF, showing that d-limonene has a potential therapeutic value for COVID-PF.
Index: D-limonene, PI3K/Akt signaling pathway, coronavirus disease 2019, coronavirus disease related pulmonary fibrosis, severe acute respiratory syndrome