Hospital readmissions following severe infections are a major economic burden on the health care system and have a negative influence on patients' quality of life . Understanding the risk factors for readmission, particularly the extent to which they could be prevented, is of a great importance . In this study we evaluated potentially preventable risk factors for 60-day readmission in patients surviving hospitalization for complicated urinary tract infection (cUTI). This was a multinational, multicentre retrospective cohort study conducted in Europe and the Middle East . Our cohort included survivors of hospitalization due to cUTI during the years 2013-2014 . The primary outcome was 60-day readmission following index hospitalization . Patient characteristics that could have influenced readmission: demographics, infection presentation and management, microbiological and clinical data; were collected via computerized medical records from infection onset up to 60 days after hospital discharge . Overall, 742 patients were included . The cohort median age was 68 years (interquartile range, (IQR) 55-80) and 43.3% (321/742) of patients were males . The all-cause 60-day readmission rate was 20.1% (149/742) and more than half were readmitted for infection [57.1%, (80/140) ]. Recurrent cUTI was the most frequent cause for readmission [46.4% (65/140) ]. Statistically significant risk factors associated with 60-day readmission in multivariable analysis were: older age (odds ratio (OR) 1.02 for an one-year increment, confidence interval (CI) 1.005-1.03), diabetes mellitus (OR 1.63 , 95% CI 1.04-2.55), cancer (OR 1.7 , 95% CI 1.05-2.77), previous urinary tract infection (UTI) in the last year (OR 1.8 , 95% CI : 1.14-2.83), insertion of an indwelling bladder catheter (OR 1.62 , 95% CI 1.07-2.45) and insertion of percutaneous nephrostomy (OR 3.68 , 95% CI 1.67-8.13). In conclusion, patients surviving hospitalization for cUTI are frequently re-hospitalized, mostly for recurrent urinary infections associated with a medical condition that necessitated urinary interventions . Interventions to avoid re-admissions should target these patients.