Patients with cancer are at increased risk of severe infections . From a cohort including 3060 patients with confirmed COVID-19, 109 (3.4 %) cancer patients were included in this study . Among them , 23 (21.1 %) patients died in the hospital . Cancer patients, especially those with hematological malignancies (41.6 %), urinary carcinoma (35.7 %), malignancies of the digestive system (33.3 %), gynecological malignancies (20 %), and lung cancer (14.3 %), had a much higher mortality than patients without cancer . A total of 19 (17.4 %) cancer patients were infected in the hospital . The clinical characteristics of deceased cancer patients were compared with those of recovered cancer patients . Multivariate Cox regression analysis indicated that a Nutritional Risk Screening (NRS2002) score ⩾ 3 (adjusted hazard ratio (HR) 11.00; 95% confidence interval (CI) 4.60-26.32; P <0.001), high-risk type (adjusted HR 18.81; 95% CI 4.21-83.93; P <0.001), tumor stage IV (adjusted HR 4.26; 95% CI 2.34-7.75; P <0.001), and recent adjuvant therapy (< 1 month) (adjusted HR 3.16; 95% CI 1.75-5.70; P <0.01) were independent risk factors for in-hospital death after adjusting for age, comorbidities, D-dimer, and lymphocyte count . In conclusion, cancer patients showed a higher risk of COVID-19 infection with a poorer prognosis than patients without cancer . Cancer patients with high-risk tumor, NRS2002 score ⩾ 3, advanced tumor stage, and recent adjuvant therapy (< 1 month) may have high risk of mortality.
Index: COVID-19, SARS-CoV-2, cancer, mortality, risk factor