Although the main vital organ affected by SARS CoV-2 is the lung, more than 20% of hospitalized patients show heart injury, however, the underlying mechanisms are still actively investigated . Inflammation or myocardial ischemia are now well-established pathogenic factors . Direct cardiac damage by the virus is likely and might account for some aspects of cardiac disease in COVID-19 patients . However, precise knowledge on mechanisms of virus entry and progression in host cells and notably in cardiac cells is necessary in order to define the broad spectrum of pathogenicity of SARS-Cov-2 on myocardium and to identify specific therapeutic targets . This review will focus on the intracellular trafficking machinery, the Achilles heel of host cells, which can be used by the virus to infect cells of the cardiovascular system.
Index: COVID-19, SARS-CoV-2, internalization, myocardium, trafficking