In March of 2020, academic research centers in Colorado were closed to prevent the spread of COVID-19 . Scientists and research staff were required to continue their work remotely with little time to prepare for the transition . This survey study used an explanatory sequential mixed method design to explore clinical and translational researcher and staff experiences of the transition to remote work during the first six weeks of the pandemic . Participants indicated the level of interference with their research and shared their experiences of remote work, how they were impacted, how they were adapting and coping, and any short or long-term concerns . Most participants indicated that remote work interfered with their research to a moderate or great degree . Participant stories illuminated the differences of remote work prior to and during COVID-19 . They described both challenges and silver linings . Here we describe three themes that highlight the challenges of transitioning to remote work during a pandemic : 1) Leadership :"This is an opportunity for leadership to lead, but leadership has disappeared"; 2) Parenting: Parents are``multitasked to death"every day; and 3) Mental health: The COVID-19 experience is``psychologically taxing"; The study findings can be used to assist academic, hospital, department, and team leaders in building community, resiliency, and support productivity during current and future crises.