BACKGROUND: Maternal vaccination for Influenza and Tetanus, Diphtheria, acellular Pertussis (TDaP) have been well studied in terms of safety and efficacy for protection of the newborn by placental passage of antibodies . Similar newborn protection would be expected after maternal vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). There is a significant and urgent need for research regarding safety and efficacy of vaccination against SARS-CoV-2 during pregnancy .
CASE PRESENTATION: A vigorous, healthy, full-term female was born to a COVID-19 naïve mother who had received a single dose of messenger RNA (mRNA) vaccine for SARS-CoV-2 3 weeks prior to delivery . IgG cord blood antibodies were detected to SARS-CoV-2 at the time of birth .
CONCLUSION: Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination.
MeSH: Antibodies, Viral, blood, COVID-19, prevention & control, COVID-19 Vaccines, administration & dosage, Female, Fetal Blood, Humans, Infant, Newborn, Pregnancy, SARS-CoV-2, immunology
Index: COVID-19, Cord blood, Maternal, Newborn, Vaccination