Background: Cardiac defects due to multisystem inflammatory syndrome in children (MIS-C) have been abundantly reported leading high morbidity among children affected by Covid-19 . We aimed to systematically assess the incidence of such cardiac abnormalities due to MIS-C in children suffering Covid-19 .
Methods: The manuscript databases including Medline, Web of knowledge, Google scholar, Scopus, and Cochrane were deeply searched by the two blinded investigators for all eligible studies based on the relevant keywords . The risk of bias for each study was assessed according to QUADAS-2 tool . Statistical analysis was performed using the Comprehensive Meta Analysis (CMA) software .
Results: In final, 21 articles (including 916 children) were eligible for the final analysis that all yielded good quality and none of the citation was determined to have high risk of bias . Considering studies focusing different cardiac abnormalities related to MIS-C yielded a pooled prevalence of 38.0% for significant left ventricular dysfunction , 20.0% for coronary aneurism or dilatation , 28.1% for ECG abnormalities or cardiac arrhythmias , 33.3% for raised serum troponin level and 43.6% for raised proBNP/BNP level . Conclusion: Although cardiac abnormalities among children suffering Covid-19 are uncommon, in the context of the MIS-C can be common and therefore potentially serious and life threatening.
Index: COVID-19, Cardiac abnormalities, children, multisystem inflammatory syndrome