OBJECTIVE: To describe the clinical characteristics and outcomes of hospitalized COVID-19 patients in a MERS-CoV referral hospital during the peak months of the pandemic .
DESIGN: A single-center case series of hospitalized individuals with confirmed SARS-CoV-2 infections in King Saud University Medical City (KSUMC), an academic tertiary care hospital in Riyadh, KSA . Clinical and biochemical markers were documented . Risks for ventilatory support, intensive care unit (ICU) admission, and death are presented .
RESULTS: Out of 12,688 individuals tested for SARS-CoV-2 by RT-PCR , 2,683 (21 %) were positive for COVID-19 . Of the latter , 605 (22 %) patients required hospitalization with a median age of 55 years, and 368 (61 %) were male . The most common comorbidities were hypertension (43 %) and diabetes (42 %). Most patients presented with fever (66 %), dyspnea (65 %), cough (61 %), elevated IL-6 (93.5 %), D-dimer (90.1 %), CRP (86.1 %), and lymphopenia (41.7 %). No MERS-CoV co-infection was detected . Overall 91 patients (15 %) died, risk factors associated with mortality were age of 65 years or older OR 2.29 [CI 1.43-3.67], presence of two or more comorbidities OR 3.17 [CI 2.00-5.02], symptoms duration of seven days or less OR 3.189 [CI (1.64 - 6.19] ) lymphopenia OR 3.388 [CI 2.10-5.44], high CRP OR 2.85 [CI 1.1-7.32], high AST OR 2.95 [CI 1.77-4.90], high creatinine OR 3.71 [CI 2.30-5.99], and high troponin-I OR 2.84 [CI 1.33-6.05].
CONCLUSION: There is a significant increase in severe cases of COVID-19 . Mortality was associated with older age, shorter symptom duration, high CRP, low lymphocyte count, and end-organ damage.
Index: COVID-19, MERS-CoV, SARS-CoV-2, mortality