Sensitivity and specificity of serological assays are key parameters for the accurate estimation of SARS-CoV-2 sero-prevalence . The aim of this study was to compare eight readily available IgG antibody tests using a panel of well-defined serum samples of pre-pandemic and pandemic origin . A cross-reaction panel included samples of patients with recent infection with either of the endemic Coronaviruses 229E, NL63, HKU1, or OC43 . Additionally, samples with high antibody levels against influenza virus, adenovirus, and during acute EBV infection were included . Previous infection with endemic coronaviruses caused a significant amount of cross-reactivity in two of the assays . In contrast, the confidence intervals for the assays of Abbott, DiaSorin, Euroimmun and Roche encompassed the value of 98% for samples with a previous endemic hCoV infection . For all assays, sensitivities were between 91.3 and 98.8% . Assay performance was independent of the usage of either nucleocapsid or spike proteins.