This article reviews the most relevant studies in the field of interventional cardiology in 2020 . In the area of coronary intervention, relevant information with respect to the percutaneous coronary intervention (PCI) vs coronary artery bypass grafting for the left main treatment has been published, as well as, the best approach in dealing with complex bifurcation lesions . There have also been significant studies regarding antiplatelet strategies in patients with acute coronary syndrome undergoing PCI, which will potentially change our clinical practice . Regarding stable angina, data point out that an initial conservative treatment can be an appropriate strategy . Finally, coronary physiology continues to generate a great interest in different clinical and anatomical contexts . The advances in the field of intervention for structural heart disease have continued to increase exponentially in the last year . The first randomized trial assessing the optimal antithrombotic treatment after transcatheter aortic valve implantation has been published and that will have clinical implications . It also highlightes the development and implantation of the first mitral and tricuspid percutaneous prosthesis, as well as, the evidence in favour of left atrial appendage closure in high-risk patients . Finally, this year has been marked by the COVID-19 pandemic which has had an impact on the clinical and research activities.