Elevated PCT level in COVID-19 was associated with higher risk of severe disease and higher risk of overall mortality . An increased PCT level of PCT in COVID-19 patients especially in severe cases would be assumed as bacterial coinfection . Could PCT level increase in SARS-CoV-2 infection without bacterial coinfection? Several SARS-CoV-2 proteins activate STAT3-dependent transcriptional pathways particularly in monocytes, that could lead to increased PCT production . STAT3α isoform causes increased ACE2 expression, resulting more SARS-CoV-2 infected cells and further production of PCT.