The novel human coronavirus disease (COVID-19) has been associated with vascular and thrombotic complications, some of which may result from endothelial dysfunction, including the posterior reversible encephalopathy syndrome (PRES). We report a case series of 8 patients with COVID-19 and PRES diagnosed at two academic medical centers between March and July of 2020 . The clinical, laboratory and radiographic data, treatment, and short-term outcomes were retrospectively analyzed . The mean age was 57.9±12 years, and 50% were women . Four patients had previous vascular comorbidities . All the patients suffered from severe pneumonia, requiring intensive care unit admission . Five patients were not hypertensive at presentation (all SBP <127 mmHg). Neurologic symptoms included seizures in 7 patients; impaired consciousness in 5 patients; focal neurological signs in 3 patients; and visual disturbances in 1 patient . All patients underwent brain magnetic resonance imaging which indicated asymmetric T2 prolongation or diffusion changes (50 %), extensive fronto-parieto-occipital involvement (25 %), vascular irregularities (12.5 %) and intracranial hemorrhage (25 %). Four patients were treated with tocilizumab . Three patients were discharged without neurologic disability, 2 patients had persistent focal neurologic deficits and 2 expired . One patient ’ s prognosis remains guarded . Together, these data support the relationship between PRES and endothelial dysfunction associated with severe COVID-19 . In patients with severe COVID-19, PRES can be triggered by uncontrolled hypertension, or occur independently in the setting of systemic illness and certain medications . Like other infectious processes, critically ill patients with COVID-19 may be at greater risk of PRES because of impaired vasoreactivity or the use of novel agents like Tocilizumab.