The novel coronavirus disease of 2019 (COVID-19) pandemic impacts the daily lives of families around the world . Sequelae are not limited to physical consequences of medical complications, but extend into social, emotional, spiritual, and psychological health . Interventions including mask wearing and physical distancing are intended to prevent viral spread but have an unintended negative effect on mental health and child development because of social isolation . Though it is too early to know the full impact of the pandemic on this generation of children, practicing pediatric clinicians are well positioned to help young people recover and thrive despite the challenges presented by the pandemic . The purpose of this article is to review emerging evidence on the impact of the COVID-19 pandemic on mental health in children, and to discuss practical steps and interventions that can be used in primary care to foster resilience in youth and their families.