With effective and safe COVID-19 vaccines beginning to be distributed across the United States, questions about who should receive the vaccine first have been the focus of public discussions . Yet, over the long-term, questions about the order of distribution will be displaced by questions about how to achieve high levels of vaccination rates . Historically, absent incentives or mandates, Americans have shown ambivalence, if not general antipathy, towards vaccinations, and vaccination rates have generally been low for many vaccines . There is evidence that vaccination requirements across educational settings are an effective policy instrument to increase vaccination rates . We administered a large national survey to assess American ’ s attitudes towards vaccination requirements across three educational settings (daycares, K-12 schools, and universities) in general and for COVID-19 specifically . Partisanship, gender, race, rurality, and perceptions about the appropriate role schools should play in providing health services are substantive predictors of public opinion . While Americans generally support vaccination mandates across all three settings for both types of requirements, support is consistently and significantly lower for COVID19 requirements . The effect of partisanship is accentuated for COVID-19 requirements as compared to general requirements . Drop off in support between general and COVID-19 specific requirements are driven by partisanship, gender, political knowledge, rurality, and having children in the household . Nonetheless, mandates are supported by a majority of Americans . Assessing Americans ’ opinions of vaccination requirements in educational settings offers an important opportunity to explore the potential of mandates as policy instrument in the government ’ s arsenal against COVID-19 and guide public policy on the issues.