Background Cystic Fibrosis (CF) is a chronic multi-system disease best cared for at Care centers with routine monitoring by interdisciplinary teams . Previously, remote home monitoring technology has been explored to augment in-person care . During the COVID-19 pandemic, traditional in-person care was limited and CF centers rapidly adapted to a telehealth delivery model . The purpose of this study was to understand how people with CF (PwCF) and families of PwCF experienced the shift to telehealthcare delivery . Methods This was a cross-sectional survey-based study conducted in 11 CF Centers . Two surveys were designed (one for adult PwCF and one for parents/guardians of PwCF) by participating CF center members with patient and family partner input . Surveys were disseminated electronically via email/text to all patients who completed a telehealth visit, and data were collected on secure Google Forms . Results Respondents rated their telehealth experiences as positive . Most were highly satisfied with their telehealth visit (77% adult , 72% pediatric) and found the visits to be highly convenient (85% for all surveyed). A majority of patients reported they had adequate time during the visit and had all questions and concerns addressed . Importantly, we also identified concerns regarding lack of in-person assessments including pulmonary function testing (PFT) and throat/sputum culture . Conclusion Telehealth was a feasible and well-accepted mechanism for delivering care in a chronic CF care model during the COVID-19 pandemic and may be useful in the post-pandemic era . Further work is needed to understand the impact of telehealth on patient outcomes, healthcare utilization and associated cost.