A systematic review with meta-analysis was performed to assess a possible association between plasma vitamin D levels and mortality in patients with COVID-19 . PubMed, EMBASE, and Cochrane Library databases were searched . Studies involving COVID-19 patients that reported an association between plasma vitamin D levels and COVID-19 mortality published until February 5 , 2020, were included . The risk ratio (RR) and confidence interval (CI) were pooled using a fixed-effects or random-effects model . A total of 11 studies that measured plasma vitamin D levels at admission were included in the meta-analysis, ten cohorts and one case-controls . Low plasma vitamin D levels (25 (OH) D) in patients with COVID-19 were not associated with mortality (RR=1.35 , 95% CI 0.84-1.86). Subgroup analysis by vitamin D cut-off (< 20 or 25 ng/ml and <10 or 12 ng/ml) showed were not associated with mortality . When the RR in mortality analysis was calculated included four studies that did not perform adjusted analysis for confounding factors, the result was 1.43 (95% CI 1.18-1.69), suggesting that confounders may have led many observational studies to incorrectly estimate the association between vitamin D status and mortality in COVID-19 patients . Deficient vitamin D levels were not associated with a higher mortality rate in patients with COVID-19 . Randomized clinical trials are needed to assess this association.