Background The COVID-19 pandemic generated an unprecedented volume of evolving clinical guidelines that strained existing clinical information systems and necessitated rapid innovation in Emergency Departments (EDs). Objectives Our team aimed to harness new COVID-19-related reliance on digital clinical support tools to re-envision the storage of and access to all clinical guidelines in our ED . Methods We used a design-thinking approach including empathizing, defining the problem, ideating, prototyping and testing to develop a low-cost, homegrown clinical information hub: E * Drive . To measure impact, we compared web traffic on E * Drive to our legacy cloud-based folder system and conducted a survey of end-users with a validated health technology utilization instrument . Results Our final product, E * Drive, is a centralized clinical information hub storing everything from clinical guidelines to discharge resources . Clinical guidelines are standardized and housed within the high-traffic E * Drive platform to increase accessibility . Since launch, E * Drive has averaged 84 unique weekly users, compared to <1 weekly user on the legacy system . We surveyed 52 clinicians for a total response rate of 47% . Prior to the E * Drive rollout 12.5% of ED clinicians felt confident accessing clinical information on the legacy system, while 76.6% of ED clinicians felt they could more easily access clinical information using E * Drive . Conclusion The COVID pandemic revealed vulnerabilities within our information dissemination system and presented an opportunity to improve clinical information delivery . Centralized web-based clinical information hubs designed around the clinician end-user experience can increase clinical guideline access in the ED.