The Coronavirus Disease 2019 (COVID-19) pandemic has taken the world into turmoil by surprise . The rapid spreading of this virus has led to an exponential increase in the number of cases . It has created a public health disaster, causing a collapse of the health system in every part of the world . Many sectors in the health area are affected, including histopathology services . The challenges and risk of viral transmission can come from various aspects and levels . For COVID-19 tests, there are even cases of no direct contact with the specimens; the specimens received infection from individuals of unknown status . The fixatives used for histopathology specimens are believed to be inactivated viruses, which can be an inactivate coronavirus . Even so, precautions have to be put in place to prevent the spread of infection to laboratory personnel, especially to those handling underfixed and fresh frozen cytology samples . Precautions must also be taken when dealing with histopathology services, by wearing full personal protective equipment and by executing other standard safety measures . The purpose of this review is to highlight the challenges faced in managing histopathology services in our centre during the COVID-19 pandemic.