Introduction Coronavirus disease is the most striking pandemic across the world that every country is addressing and talking about it now.Nurses deliver the highest level of functioning in the health care team . Nurses need to understand theCOVID-19preparedness and response process . Therefore, it becomes very important to assess a nurse's knowledge of preparedness and response to Corona Virus Disease (Covid-19). Methods The research approach was quantitative in nature by using the descriptive cross-sectional surveyamong nurses working underMOHHospitals inNajranregion, KSA . The sample participated in the survey was 594 and thetool used for the studywas a modifiedquestionnaire on Nurse's preparedness and response toCOVID-19 . Thequestionnaire contained five parts and thefirst part included basic information of the nurses andthe second partwas composedof yes or noquestions assessing the nurse'sKnowledge onCOVID-19 preparedness and thethird part composed of facility and response readiness to triage screening and the fourth part consist of nurses preparedness and readiness on COVID and fifth part composed ofnurse's preparedness and readiness onperonealprotective equipment's and the study was approved byInstitutional Review Board (IRB). Data was presented by using descriptive and inferential statistics . Results Our study results found that overall knowledge ofCOVIDpreparedness was adequate . However, the nurse's preparedness on personal protective equipment was moderate . Majority of respondents were Registered Nurses 587 (98.9 %) and most of the respondentswere employed by theMinistry of Health 586 (98.7 %) andthe nurse's knowledge of preparedness was 456 (76.8 %) andthe facilities preparedness and response readiness was 549 (92.4) and adequate supply ofpersonal protective equipment (PPE) 519 (87 . 3 %). Conclusion The findings of the studyexhibitthat nurses have an adequate level of knowledge towards thepreparedness and response to coronavirus diseases.