The COVID-19 pandemic has infected millions of people worldwide and many countries have been suffering from a large number of deaths . Acknowledging the ability of SARS-CoV-2 to mutate into distinct strains as an RNA virus and investigating its potential to cause reinfection is important for future health policy guidelines . It was thought that individuals who recovered from COVID-19 generate a robust immune response and develop protective immunity, however, since the first case of documented reinfection of COVID-19 in August 2020, there have been a number of cases with reinfection . Many cases are lacking genomic data of the two infections and it remains unclear whether they were caused by different strains . In the present study, we undertook a rapid systematic review to identify cases infected with different genetic strains of SARS-CoV-2 confirmed by polymerase-chain reaction and viral genome sequencing . A total of 17 cases of genetically confirmed COVID-19 reinfection were found . One immunocompromised patient had mild symptoms with the first infection, but developed severe symptoms resulting in death with the second infection . Overall , 68.8% (11/16) had similar severity , 18.8% (3/16) had worse symptoms, and 12.5% (2/16) had milder symptoms with the second episode . Our case series shows that reinfection with different strains is possible and some cases may experience more severe infections with the second episode . The findings also suggest that COVID-19 may continue to circulate even after achieving herd immunity through natural infection or vaccination suggesting the need for longer term transmission mitigation efforts.