Objective: Chagas disease (CD) continues to be a major public health burden in Latina America, where co-infection with SARS-CoV-2 can occur . However, information on the interplay between COVID-19 and Chagas disease is lacking . Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients .
Methods: Patients with COVID-19 diagnosis were selected from the Brazilian COVID-19 Registry, a prospective multicenter cohort, from March to September , 2020 . CD diagnosis was based on hospital record at the time of admission . Study data were collected by trained hospital staff using Research Electronic Data Capture (REDCap) tools . Genetic matching for sex, age, hypertension, DM and hospital was performed in a 4:1 ratio .
Results: Of the 7,018 patients who had confirmed infection with SARS-CoV-2 in the registry, 31 patients with CD and 124 matched controls were included . Overall, the median age was 72 (64.-80) years-old and 44.5% were male . At baseline, heart failure (25.8% vs. 9.7 %) and atrial fibrillation (29.0% vs. 5.6 %) were more frequent in CD patients than in the controls (p <0.05 for both). C-reactive protein levels were lower in CD patients compared with the controls (55.5 [35.7 , 85.0] vs. 94.3 [50.7 , 167.5] mg/dL). Seventy-two (46.5 %) patients required admission to the intensive care unit . In-hospital management, outcomes and complications were similar between the groups .
Conclusions: In this large Brazilian COVID-19 Registry, CD patients had a higher prevalence of atrial fibrillation and chronic heart failure compared with non-CD controls, with no differences in-hospital outcomes . The lower C-reactive protein levels in CD patients require further investigation.