The present review describes the various roles of cyclodextrins (CDs) in vaccines against viruses and in antiviral therapeutics . The first section describes the most commonly studied application of cyclodextrins-solubilisation and stabilisation of antiviral drugs; some examples also refer to their beneficial taste-masking activity . The second part of the review describes the role of cyclodextrins in antiviral vaccine development and stabilisation, where they are employed as adjuvants and cryopreserving agents . In addition, cyclodextrin-based polymers as delivery systems for mRNA are currently under development . Lastly, the use of cyclodextrins as pharmaceutical active ingredients for the treatment of viral infections is explored . This new field of application is still taking its first steps . Nevertheless, promising results from the use of cyclodextrins as agents to treat other pathologies are encouraging . We present potential applications of the results reported in the literature and highlight the products that are already available on the market.