BACKGROUND: Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS).
OBJECTIVE: To describe the clinical characteristics of patients with ARDS-COVID-19 . MATERIALS AND
METHODS: This study involved 197 male Egyptian participants, among them111 COVID-19 patients presented with ARDS , 60 COVID-19 patients presented with non-ARDS, and 26 Non-COVID-19 patients . We reported the analysis results of clinical and laboratory information, including blood routine tests, blood biochemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and C-reactive protein (CRP) ], thrombotic activity (D-dimer) and serum ferritin and lactate dehydrogenase (LDH).
RESULTS: The levels of hemoglobin, AST, creatinine, monocyte count, monocyte%, RBC count, TLC, and platelet count were not significantly different among the groups . The lymphopenia and increased CRP, ALT, D-dimer, ferritin, and LDH were observed in patients with ARDS-COVID-19 .
CONCLUSION: COVID-19 patients with ARDS presented with lymphopenia, increased thrombotic activity, increased CRP, LDH, and ferritin levels . The results revealed that CRP, D-dimer, LDH levels, and lymphopenia have a significant association with the COVID-19 severity and can be used as biomarkers to predict the disease severity.