The Coronavirus (COVID-19) pandemic had a huge impact on all sectors around the world . In particular, the healthcare system has been subject to an enormous pressure that has surpassed its ability in many instances . Additionally, the pandemic has called for a review of our daily medical practices, including our approach to colorectal cancer management where treatment puts patients at high risk of virus exposure . Given their higher median age, patients are at an increased risk for severe symptoms and complications in cases of infection, especially in the setting of immunosuppression . Therefore, a review of the routine colorectal cancer practices is needed to minimize risk of exposure . Oncologists should weigh risk of exposure versus the patient's oncologic benefits when approaching management . In addition, treatment protocols should be modified to minimize hospital visits and admissions while maintaining the same treatment efficacy . In this review, we will focus on challenges that colorectal cancer patients face during the pandemic, while highlighting the priority in each case . We will also discuss the evidence for potential modifications to existing treatment plans that could reduce infectious exposure without compromising care . Finally, we will discuss the impact of the socio-economic difficulties faced by Lebanese patients due to a poor economy toppled by an unexpected pandemic.