For precise health status monitoring and disease diagnostics in the current COVID-19 pandemic, it is essential to detect various kinds of target signals robustly under high noise and strong interferences . Moreover, the health monitoring system is preferred to be realized in a small form factor for convenient mass deployments . A CMOS-integrated coherent sensing platform is proposed to achieve the goal, which synergetically leverages quadrature coherent photoacoustic (PA) detection and radar sensing for versatile healthcare . By utilizing configurable mixed-signal quadrature coherent PA detection, high sensitivity and enhanced specificity can be achieved . In-phase (I) and quadrature (Q) templates are specifically designed to accurately sense and precisely reconstruct the target PA signals coherently . By mixed-signal implementation leveraging an FPGA to generate template waveforms adaptively, accurate capturing and precise reconstruction on the target PA signal can be attained . The multiplication between the received PA signal and the templates is implemented efficiently in analog-domain by the Gilbert cell on-chip . In vivo temperature monitoring was realized based on the integrated PA sensing platform fabricated in 65-nm CMOS technology . With the help of an integrated radar sensor deployed in the indoor scenario, noncontact monitoring on respiration and heartbeat rates can be attained . By complementary usage of PA-EM sensing, comprehensive and cognitive health status monitoring and remote disease diagnostics can be achieved for the current global COVID-19 pandemic and the future pervasive healthcare in the Internet of Everything (IoE) era.