Analogs of nucleosides and nucleotides represent a promising pool of potential therapeutics . This work describes a new synthetic route leading to 2'-deoxy-2'-fluorotetradialdose D-nucleoside phosphonates . Moreover, a new universal synthetic route leading to tetradialdose d-nucleosides bearing purine nucleobases is also described . All new compounds were tested as triphosphate analogs for inhibitory potency against a variety of viral polymerases . The fluorinated nucleosides were transformed to phosphoramidate prodrugs and evaluated in cell cultures against various viruses including influenza and SARS-CoV-2.