Lethal or critical COVID-19 occurs most in infected hosts with certain risk factors such as advanced age or pre-existing disease . Host metabolic status significantly affects the clinical presentations of SARS-CoV-2 infection . Individual risk management is thus crucial for preventing severe COVID-19 . Such susceptibility is individual, depending on a multitude of factors . Personalized risk assessment requires the inclusive analysis of big health data to stratify individual risk and derive a customized action plan . Personalized medicine requires shifting from the virology aspect per se to the whole individual's consideration, including dietary pattern, nutritional status, supporting lifestyle, co-existing diseases, and environmental factors . In this short communication, we discuss the individual management strategy for SARS-CoV2 infection as a step towards future personalized healthcare.