Emerging evidence suggests that novel COVID-19 is associated with increased prothrombotic state and risk of thromboembolic complications, particularly in severe disease . COVID-19 is known to predispose to both venous and arterial thrombotic disease . We describe a case of a 61-year-old woman with history of type II diabetes, hypertension and hyperlipidaemia who presented with dry cough and acute abdominal pain . She was found to have a significantly elevated D-dimer, prompting imaging that showed thrombi in her right ventricle and aorta . She had rapid clinical deterioration and eventually required tissue plasminogen activator with subsequent durable clinical improvement . This case highlights a rare co-occurrence of venous and arterial thrombi in a patient with severe COVID-19 . Further studies are needed to clarify the molecular mechanism of COVID-19 coagulopathy, the utility of D-dimer to predict and stratify risk of thrombosis in COVID-19, and the use of fibrinolytic therapy in patients with COVID-19.