This study aimed to explore influencing factors for the psychological impact of coronavirus disease 2019 (COVID-19) on Wuhan college teachers, posttraumatic stress symptoms in particular, so as to inform evidence-based strategy development to ameliorate such adverse impacts . An online survey was conducted from 26 to 29 April 2020, and 1650 teachers (47.54% male; M = 40.28 years, SD = 8.3 years) enrolled in Wuhan universities and colleges participated . The results showed that the overall incidence of posttraumatic stress disorder (PTSD) among college teachers was as high as 24.55%, but the average level of PTSD score was low (M = 1.06, SD = 0.72). Logistic regression analysis showed that for those with confirmed COVID-19, the ratio was much higher, up to 2.814 (95% confidence interval [CI]: [1.542 , 5.136], p <0.001); that is, compared with those without symptoms, the ratio of PTSD increased by 181% . For those who had family members or relatives who died of COVID-19, the ratio was 5.592 (95% CI: [2.271 , 13.766], p <0.001), 459% higher than those who had no one who died . But the living places during the pandemic had no significant effect on PTSD . The findings suggest that mental health services reducing PTSD should be provided . Teachers who confirmed COVID-19 or lost loved ones to COVID-19 should be given particular care.