Coronavirus disease (COVID-19) presents a broad spectrum of clinical manifestations ranging from an asymptomatic to a severe clinical course . The host genetic background influence on the susceptibility and outcome of multiples infectious diseases has been previously reported . Herein, we aimed to describe relevant identified genetic variants and those potentially related to the inter-individual variability of COVID-19 susceptibility and/or severity considering the physiopathological pathway of the disease The HLA-A * 25:01, -B * 15:27, -B * 46:01, -C * 01:02, and -C * 07:29 alleles have been associated with COVID-19 susceptibility; while HLA-A * 02:02, -B * 15:03, and -C * 12:03 have been identified as low-risk alleles . Variants in cytokine genes such as IL1B, IL1R1, IL1RN, IL6, IL17A, FCGR2A, and TNF could be related to disease susceptibility and cytokine storm, and/or COVID-19 complications (e.g., venous thrombosis). Several variants in ACE2 and TMPRSS2 affecting the expression of the receptors related to COVID-19 have been associated with the disease susceptibility and risk factors . Finally, two GWAS have identified the loci 3p21.31 (LZTFL1, SLC6A20, CCR9, FYCO1, CXCR6, and XCR1) and 9q34.2 (ABO) with COVID-19 severity . Heterogeneous results in the association of genetic variants with COVID-19 susceptibility and severity were observed . The mechanism of identified risk-genes and studies in different populations are still warranted.