BACKGROUND: Outcome for critically ill patients with COVID-19 treated with continuous renal replacement therapy (CRRT) is largely unknown . We describe mortality and renal outcome in this group .
METHODS: This observational study was conducted at a university hospital in Sweden . We studied critically ill adult COVID-19 patients with Acute Kidney injury (AKI) who received CRRT .
RESULTS: In 451 patients, AKI incidence was 43.7% . 18.2% received CRRT . Median age of CRRT patients was 60 years (IQR 54-65), 90% were male, median BMI was 29 (IQR 25-32), 23.2% had Diabetes , 37.8% hypertension and 6.1% chronic kidney disease prior to admission . 100% required mechanical ventilation . 8.5% received Extra Corporeal Membrane Oxygenation . Median length of stay was 23 days (IQR 15-26). ICU mortality was 39% and 90-day mortality was 45.1% . Age, baseline creatinine values and body weight change were associated with 60 days mortality . Of the survivors, no patients required dialysis at hospital discharge , 73.8% recovered renal function and a median 10.5% of body weight was lost during admission .
CONCLUSIONS: Critically ill COVID-19 patients with AKI who received CRRT had a 90-day mortality of 45.1% . At follow-up, three quarters of survivors had recovered renal function . This information is important in the clinical management of COVID-19.