The use of health information technology (HIT) during the coronavirus disease 2019 (COVID-19) pandemic has rapidly increased . During the pandemic, HIT has been used to provide telehealth services, education on the severe acute respiratory syndrome coronavirus 2 disease, updates on epidemiology and treatments, and most recently, access to scheduling systems for the COVID-19 vaccines . Disparities and health equity, with higher rates of illness, hospitalization, and death, during the pandemic has been documented in Hispanic or Latinx, black, and Native American or Alaska Native persons . Social determinants of health affect these persons disproportionately, including having lower socioeconomic status, lack of reliable transportation, lack of good quality broadband, being employed as an``essential worker ,"lack of quality housing, and access to and distrust of the government and health care setting . Patients who have limited or low health literacy will also be at risk for inequitable access to the COVID-19 vaccine owing to the complexities associated with the current vaccine distribution models and the heavy reliance on HIT.