ABSTRACT: This study investigated the association between COVID-related myalgia experienced by patients at hospital admission and the presence of post-COVID symptoms . A case-control study including patients hospitalised due to COVID-19 between February 20 and May 31 , 2020 was conducted . Patients reporting myalgia and patients without myalgia at hospital admission were scheduled for a telephone interview 7 months after hospital discharge . Hospitalisation and clinical data were collected from medical records . A list of post-COVID symptoms with attention to musculoskeletal pain was evaluated . Anxiety and depressive symptoms, and sleep quality were likewise assessed . From a total 1,200 hospitalised COVID-19 patients , 369 with and 369 without myalgia at hospital admission were assessed 7.2 months (SD 0.6) after hospital discharge . A greater proportion (P=0.03) of patients with myalgia at hospital admission (20 %) showed & #8805; 3 post-COVID symptoms when compared with individuals without myalgia (13 %). A higher proportion of patients presenting myalgia (OR1.41 , 95% CI 1.04-1.90) exhibited musculoskeletal post-COVID pain when compared to those without myalgia . The prevalence of musculoskeletal post-COVID pain in the total sample was 38% . Fifty percent of individuals with pre-existing musculoskeletal pain experienced a worsening of their symptoms after COVID-19 . No differences in fatigue, dyspnoea, anxiety/depressive levels or sleep quality were observed between myalgia and non-myalgia groups . The presence of myalgia at hospital admission was associated with pre-existing history of musculoskeletal pain (OR1.62 , 95% CI 1.10-2.40). In conclusion, myalgia at the acute phase was associated with musculoskeletal pain as long-term post-COVID sequelae . Additionally, half of patients with pre-existing pain conditions experienced a persistent exacerbation of their previous syndromes.