Introduction: Several evaluations of deaths in persons of advanced age associated with SARS-CoV2 can be found in the international literature . The aim of this work was the evaluation of deaths associated with SARS-CoV2 of persons of younger or middle age (up to 50 years) at the Institute of Legal Medicine in Hamburg, Germany, with presentation of frequency, comorbidities and disease courses . Material and methods: A total of 735 SARS-CoV-2-associated cases of decedents with registered addresses in Hamburg were evaluated in 2020 at the Institute of Legal Medicine in Hamburg, Germany, using various examination methods . The selection and performance of the respective methods was based on the consent given by the relatives . In addition, more autopsies of decedents with a registered address outside Hamburg and positive SARS-CoV2 detection were performed . Results and conclusion: Of the 735 decedents 9 with a registered Hamburg address and 3 of the deaths studied with an external registered address (nâ¯= 12; 7 men and 5 women) were aged 50 years or younger, with an average age of 39.8 years . Essentially, there were cardiovascular, neurological, and malignant pre-existing diseases, as well as obesity . The SARS-CoV2 was detected post-mortem for the first time in two cases; these were found to have a virus-independent cause of death . Of the individuals 7 died from COVID-19 pneumonia , 3 individuals from the consequences of the necessary intensive medical treatment.Several studies have demonstrated an association between obesity and severe SARS-CoV-2-related disease progression, particularly in younger patients and this was confirmed in the legal medicine study population.