There have many major history-defining epidemics and pandemics in the 21st century . It is well known that acute infections can cause cardiovascular (CV) complications especially in those with underlying cardiac disease . The variation in rates and types of CV disease complications in major 21st century epidemics and pandemics varies greatly . The coronavirus disease 2019 (COVID-19) pandemic has caused the turmoil of the century and has COVID-19 has resulted in substantial human and economic loss . . The novelty of COVID-19 and emerging CV effects is a new entity . In this review, we discuss the major epidemics and pandemics of the 21st century and associated CV disease complications . .